Current Issue : January-March Volume : 2025 Issue Number : 1 Articles : 1 Articles
Diabetes mellitus has been a significant challenge to the health sector, particularly in developing nations where type 2 diabetes accounts for 90% of cases. Diabetic complication arises from excessive production of free radical. Hence, the study was carried out to evaluate the physicochemical parameters, antioxidant and antidiabetic activity of Treculia africana Deane. (Moraceae) extracts. The dried powdered leaves, stem-bark and root of T. africana were extracted in methanol. Extracts and fractions were subjected to: phytochemical, physicochemical analyses, in-vitro antioxidant and antidiabetic effects using 1-Diphenyl-2-Picrylhydrazyl and alpha amylase inhibition method. The standard drugs were ascorbic and gallic acids for antioxidant while metformin for antidiabetic. Absorbance for antioxidant, antidiabetic measured at 517 nm and 540 nm respectively. Phytochemical revealed the presence of some secondary metabolites. Physicochemical analysis of the leaves, stem bark and root showed different values for total ash (12.45, 15.40, 19.30 %), acid insoluble ash (7.26, 7.90, 10.08%), water insoluble ash (3.10, 2.93, 6.79 %) and moisture content (18.70, 19.50, 14.30%) respectively. The stem bark extract and n-hexane fraction displayed highest scavenging activity with IC50 of 0.465 ± 20.02µg/ml and 0.0433 ± 53.43µg/ml respectively against antioxidant agent in comparison to reference drug, ascorbic and gallic acid with IC50 of 28.17±39.84 and 5.14±16.04 µg/ml. The stem bark extract exhibited the highest percentage inhibition (84.80±4.16) as compared to standard drug, metformin (80.38 ± 5.23). The crude methanol stem bark and n-hexane fraction had significant alpha–amylase inhibitory and antioxidant activity than the other extracts....
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