Current Issue : January-March Volume : 2025 Issue Number : 1 Articles : 2 Articles
Liposomal carrier system incorporating phytosomal forms of silymarin was formulated. Formulations were characterized by particle size, zeta potential, DSC thermogram, XRD data and TEM image. In-vitro release profile showed better release of silymarin from all liposomes compared to free drug with highest release from conventional and DP-liposome at pH 1.2 and from Conventional and PEGylated at pH 7.4. Conventional and PEGylated liposomal formulations showed better protection to Chang liver cells against cytotoxicity of paracetamol. The improved in-vivo function of conventional liposomal formulation was also ascertained by histopathology reports in the tested hepatotoxic models. Conventional liposome showed a significant elevation in antioxidant levels compared to silymarin alone in Wistar rats in all three hepatotoxic models Investigation of the pharmacokinetic results from the oral administration of silymarin and its conventional liposomes showed that conventional liposomes increased Cmax more than five times compared to silymarin alone in normal rats and almost six times in alcoholic liver disease condition in rat. Thus, liposomal formulation of silymarin is a suitable candidate and can be used as liver protectant....
Diabetes mellitus has been a significant challenge to the health sector, particularly in developing nations where type 2 diabetes accounts for 90% of cases. Diabetic complication arises from excessive production of free radical. Hence, the study was carried out to evaluate the physicochemical parameters, antioxidant and antidiabetic activity of Treculia africana Deane. (Moraceae) extracts. The dried powdered leaves, stem-bark and root of T. africana were extracted in methanol. Extracts and fractions were subjected to: phytochemical, physicochemical analyses, in-vitro antioxidant and antidiabetic effects using 1-Diphenyl-2-Picrylhydrazyl and alpha amylase inhibition method. The standard drugs were ascorbic and gallic acids for antioxidant while metformin for antidiabetic. Absorbance for antioxidant, antidiabetic measured at 517 nm and 540 nm respectively. Phytochemical revealed the presence of some secondary metabolites. Physicochemical analysis of the leaves, stem bark and root showed different values for total ash (12.45, 15.40, 19.30 %), acid insoluble ash (7.26, 7.90, 10.08%), water insoluble ash (3.10, 2.93, 6.79 %) and moisture content (18.70, 19.50, 14.30%) respectively. The stem bark extract and n-hexane fraction displayed highest scavenging activity with IC50 of 0.465 ± 20.02µg/ml and 0.0433 ± 53.43µg/ml respectively against antioxidant agent in comparison to reference drug, ascorbic and gallic acid with IC50 of 28.17±39.84 and 5.14±16.04 µg/ml. The stem bark extract exhibited the highest percentage inhibition (84.80±4.16) as compared to standard drug, metformin (80.38 ± 5.23). The crude methanol stem bark and n-hexane fraction had significant alpha–amylase inhibitory and antioxidant activity than the other extracts....
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